Pharmacological approach to anaphylactic shock (AS). III Effects of theophylline in preventing shock —

Anaphylactic shock to raspberry.

Anaphylactic Shock

Anaphylactic shock is an unexpected, sudden and sometimes deadly event that attacks the patient in 75% of the cases without pre-existent history of allergy. In general, drugs, hymenopteric poisons and nutrients (according to the recent concept) are responsible. Beside the classical IgE-mediated anaphylactic shock there exists another anaphylactic shock, identical in its clinical picture and tre...

Lipoids as Inhibitors of Anaphylactic Shock

1. The antitryptic titer of the serum can be increased by subcutaneous injections of serum lipoids (antitrypsin) and of the lipoids from egg yolk. 2. Animals so injected show a relative immunity to acute anaphylactic shock (two minimum lethal doses). 3. Extraction of lipoids contained in antigens increases the toxicity of the antigen when injected into a sensitized animal. 4. Sublethal doses of...

Anaphylactic Shock by Azodyes

Experiments are described which show that anaphylactic shock can be induced in animals sensitized with azoproteins by injecting them with azodyes containing the same azo components as the sensitizing antigen. The anaphylactic reactions are specific and occur with quantities of the dyes as small as fractions of milligrams.

The Mechanism of Anaphylactic Shock

1. The serum ferments are practically unaltered by a primary injection of foreign protein. 2. During the course of sensitization the injection of the antigen is followed by the mobilization of a non-specific protease which increases in rapidity and intensity as the maximum period of sensitization is reached. 3. Acute shock is accompanied by: (a) The instantaneous mobilization of a large amount ...